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Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

95 (43), e4821 (2016)

Over the long term, ketamine has been shown to alter the expression of NMDA receptors and reduce neuro-inflammation in the rat and mouse models of pain, which has been correlated with reductions in neuropathic pain